Amarnath Natarajan

Amar Natarajan, Ph.D. Professor and James L. Winkle Endowed Chair Division of Pharmaceutical Sciences College of Pharmacy Professor Department of Internal Medicine College of Medicine University of Cincinnati Cincinnati, OH 45267-0514 Dr. Natarajan will chair the session "Harnessing novel E3 ligase biology to broaden the target space" - The expanding understanding of E3 ubiquitin ligase biology is creating new opportunities to target disease-associated proteins previously considered undruggable. Despite the presence of approximately 600 human E3 ligases, targeted protein degradation technologies have predominantly relied on cereblon (CRBN) and von Hippel–Lindau (VHL), limiting their therapeutic scope. This session will highlight innovative strategies to discover, characterize, and exploit alternative E3 ligases for therapeutic applications. Presentations will explore high-throughput CRISPR screening to identify E3 ligases regulating TBK1 activation, demonstrating opportunitie