David Adamuz Comino

My research focuses on identifying novel biomarkers to improve the differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer’s disease (AD), two neurodegenerative disorders with considerable clinical overlap. I am a PhD researcher at the Germans Trias i Pujol Research Institute, where I investigate the role of platelets as a potential source of biomarkers, with particular interest in their inflammatory and immunological profiles in DLB. My work integrates molecular biology, gene expression analysis, protein profiling, and transcriptomic and bioinformatic approaches to characterize disease-specific molecular signatures and gain insight into the mechanisms underlying neurodegeneration. I am also involved in standardizing seed amplification assays for the detection of alpha-synuclein pathology and in investigating platelet activation using flow cytometry. My research combines experimental and computational approaches to better understand the molecular changes associated with