Pengfei Guo

Dr. Pengfei Guo is a postdoctoral researcher at the University of Pennsylvania, where he develops and applies spatial multi-omics technologies to investigate gene regulation and tissue architecture in human disease. He received his Ph.D. from Zhejiang University and previously worked as a research scholar at the University of Nevada before joining UPenn. As a first author, he has published in leading journals, including Cell (2026), Nature Methods (2025), Nature Communications (2022, 2025), and eLife (2024). He has a strong track record of developing new experimental approaches that expand the measurable dimensions of tissue biology. His work bridges technology development with disease-focused applications, enabling new ways to profile genome organization, epigenetic regulation, and transcriptional programs directly in intact tissues. His research integrates genomics, epigenomics, transcriptomics, spatial profiling, and computational analysis to uncover how regulatory mechanisms shape