Abdel Ali Belaidi

Abdel Ali Belaidi is Head of the Neurodegeneration Therapeutics Laboratory at The Florey Institute of Neuroscience and Mental Health and an Honorary Senior Research Fellow at the University of Melbourne. His research focuses on mechanisms of neurodegeneration in Alzheimer’s disease, with particular interest in apolipoprotein E (apoE), apoE receptors, tau pathology, ferroptosis, lipid metabolism and neuronal resilience. He is particularly interested in how apoE isoforms and apoE lipidation influence neuronal uptake, endolysosomal trafficking and autophagic degradation of proteins, and how these processes contribute to the development of tau pathology. His laboratory uses complementary cellular and transgenic animal models to investigate how apoE interacts with its different receptors and how these receptor-dependent pathways regulate proteostasis, lipid peroxidation and neuronal survival. His recent work identified apoE as a potent regulator of ferroptosis and is examining how apoER2 si