Claudio A. Cuello

Dr Cuello has made pioneering publications on dendritic release of neurotransmitters, the localization and role of central and peripheral neuropeptides, trophic factor-induced repair and synaptogenesis, novel applications of monoclonal antibodies in the neurosciences. His early collaborative contributions with Cesar Milstein to the hybridoma technology have been highlighted in ”The Lock and Key” of Medicine: Monoclonal antibodies and their transformation of healthcare' , Yale Universiy Press, NY, 2015. More recently has made contributions Alzheimer's research by discovering novel aspects of amyloid driven CNS inflammation and a brain metabolic pathway responsible for the activity-dependent release, maturation and extracellular degradation of NGF. A pathway found by his lab to be dysregulated in the Alzheimer’s disease (AD) pathology, even at preclinical stages in Down syndrome and in cognitively normal individuals with incipient AD pathology. These changes in the NGF metabolic pathway