David M. Holtzman

David Holtzman is Professor, scientific director of the Hope Center for Neurological Disorders, Director of the Knight Alzheimer’s Disease Research Center, and former Chair of Neurology at Washington University from 2003-2021. Some of his lab’s accomplishments include showing in part how APOE contributes to AD, development of plasma and CSF biomarkers for AD, demonstration that synaptic activity and sleep affect Aβ and tau levels in vivo, describing the effects of APOE, TREM2, and both the innate and adaptive immune response on tau-mediated neurodegeneration. Several of his honors include being a recipient of the Potamkin prize and MetLife award for research on Alzheimer’s disease, Rainwater Prize for outstanding innovation in neurodegenerative disease research, Baye-Dole Coalition 2026 Faces of Innovation award, election to the National Academy of Medicine, and being appointed to the National Advisory council of the NINDS and NIA. Holtzman has trained over 80 graduate students, post-d